Cho S, Sung HK, Nguyen K, Lei Y, Wannaiampikul S, Lee B, Tam E, Luo Y, Petrotchenko EV, Borchers CH, Prentice KJ, Summers SA, Burger D, Sweeney G.
Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients Reveals Pro-Oxidative and Pro-Inflammatory Lipid Signatures Correlating with Metabolic Dysfunction.
J Extracellular Vesicles. (2026) Feb;15(2):e70229. https://doi.org/10.1002/jev2.70229
Tang J, Chung WY, Pulente SM, Lei Y, Nguyen K, Tam E, Morrow NM, Lorenzen-Schmidt I, Xiao F, Zani A, Burger D, Sung HK, Mulvihill EE, Sweeney G.
Extracellular vesicles modulation by an adiponectin receptor agonist provides cardioprotection
for myocardial ischemic injury
Advanced Healthcare Materials (2026) Apr 14:e05837. doi: 10.1002/adhm.202505837.
Tang J, Joyce N, Laval T, Tam E, Sung HK, Ouimet O, & Sweeney G.
Loss of Rab8a-Dependent Tethering of Lipid Droplets to Mitochondria Contributes to Hypoxia-Reoxygenation Injury
Med Comm (2026) in press
Oliver B, Sun M, Lee YS, Cho S, Zhu T, Durgan D & Sweeney G.
Gut-Derived Bacterial Extracellular Vesicles: The Microbial Dark Matter Contributing to Host Inflammation and Cardiometabolic Disease
Gut Microbes (2026) 18(1):2672794. doi: 10.1080/19490976.2026.2672794
Lei Y, Li B, Gosse T, Cho S, Sung HK, Chen J, Sweeney G.
Systemic Metabolomic Remodeling in Pressure Overload-Induced Heart Failure Indicates Modulation of a Gut-Liver-Heart Axis by the Adiponectin Receptor Agonist ALY688.
Metabolites. (2026) 16(1):38. doi: 10.3390/metabo16010038.
Wannaiampikul S, Lee B, Chen J, Prentice KJ, Ayansola R, Xu A, Santosa S, Pantopoulos K, Sweeney G
Integrated metabolomics and metagenomics analysis defines a unique signature of metabolic syndrome in a Thai population
Journal of Nutritional Biochemistry (2026) 110327. doi:10.1016/j.jnutbio.2026.110327
Li Y, Fillebeen C, Li S, Chen J, Sweeney G, Pantopoulos K
High Dietary Carbonyl Iron Reshapes the Gut Microbiome and Impairs Hepatic Insulin Sensitivity in a Time-Dependent Manner.
FASEB J. (2026) 40(4):e71626. doi: 10.1096/fj.202504722R.
Gu W, Wilkinson N, Fillebeen C, Blackburn DM, Sahinyan K, Bonneil E, Zhao T, Luo Z, Soleimani VD, Richard V, Borchers CH, Koulman A, Jenkins B, Michalke B, Zischka H, Sailer J,
Venkataramani V, Iliopoulos O, Sweeney G, Pantopoulos K
IRP1 deficiency alters mitochondrial metabolism and protects against metabolic syndrome
pathologies.
JCI Insight. (2026) 11(4):e183247. doi: 10.1172/jci.insight.183247
Bahit MC, Gibson CM, Lei, Y, Hsu HH. Scherer PE & Sweeney G
Prospects for adiponectin-based therapeutics in myocardial ischemia reperfusion injury
Pharmacology &Therapeutics (2024: submitted)
Robin N, Barra NG, Foley KP, Li YJ, Tamrakar AK, Patoli D, Rebalka IA, Nguyen K, Davis R, Chan D, Duggan B M, Henriksbo BD, Gregorevic P, Watt KI, Sweeney G, Hawke TJ, Py BF, Schertzer JD
NLRP3 inflammasome promotes statin-induced myopathy via protein-prenylation and hippo-YAP1.
Science Advances (2026 resubmitted)
Tang J, Crewe C, Lei Y & Sweeney G.
Extracellular vesicle mediated crosstalk between cardiometabolic tissues: mechanisms, pathophysiological significance and therapeutic potential
Physiological Reviews (2026 invited)
Sung HK, Tang J, Lei L, Nguyen K, Tam E, Wu J, Li RK, Richard V, Borchers C, Antounians L, Burger D, Zani A, Sweeney G.
ALY688 Protects Against Myocardial Ischemia-Reperfusion Injury via Direct Effects and Rab8a-dependent Extracellular Vesicles.
J Extracellular Vesicles. (2026 resubmitted)
Ahmed SM, Tang J, Nguyen K, Sung HK, Burger D, Abdul-Sater AA, Sweeney G.
The adiponectin mimetic peptide ALY688 mitigates high glucose-induced cell death via an autophagy-dependent mechanism.
Biomedical Journal (2026 submitted)
Tang J, Sung HK, Lei Y, Teerawongsuwan S, Rungsiwiwut R, Wannaiampikul S, Chen J, Ridany I, Richard V, Borchers C, Kim YJ, Cho S, Coquant G, Corr SC, Wu J, Li RK, Wang C, Abdul-Sater AA, Sweeney G.
ALY688 Confers Cardioprotection Through Macrophage TGFβ-Mediated Treg/Th17 Gut-Heart Crosstalk
Pharmacological Research (2026 submitted)
2025
Perry CGR & Sweeney G
Targeting Scpep1 inhibition as a treatment in myocardial infarction: Editorial.
European Heart Journal (2025) 46(26):2595-2597. https://academic.oup.com/eurheartj/article/46/26/2595/8125571
Cho S, Tam E, Nguyen K, Lei Y, Fillebeen C, Pantopolous K, Sung HK, & Sweeney G
ω-6 PUFA-enriched cardiomyocyte membrane phospholipid composition increases the susceptibility to iron-induced ferroptosis and inflammation
Apoptosis (2025) doi: 10.1007/s10495-025-02121-0
Nguyen K, Tang J, Cho S , Gatica D, Russell RC, Sung HK & Sweeney G
ALY688 attenuates iron-induced ER stress and insulin resistance via activation of ER-phagy.
Diabetes (2025) 74(10):1761-1774. doi:10.2337/db25-0405
Lei Y, Sung HK, Burger D & Sweeney G
Strategies for Promoting Improved Healthspan: The Therapeutic Potential of Adiponectin and Extracellular Vesicles in Age-related Diseases
Ageing Research Reviews (2025) 111:102823. doi: 10.1016/j.arr.2025.102823
Chung WY, Kim Y, Cho S, Burger D & Sweeney G
Role of Extracellular Vesicles in Pathogenesis of Cardiometabolic disease in Aging
Mechanisms of Ageing and Development (2025) 226:112078. doi: 10.1016/j.mad.2025.112078.
Sweeney G. & Burger D
Is secondary vesicle release an underappreciated component of extracellular vesicle signalling?
Journal of Extracellular Vesicles (2025) Nov;14(11):e70202. https://doi.org/10.1002/jev2.70202
Tam E, Ouimet M, & Sweeney G
Role of adiponectin-stimulated autophagy in cardioprotection
Journal of Lipid & Atherosclerosis (2025) 14(1):40-53. doi: 10.12997/jla.2025.14.1.40.
Lei Y, Liu Y, Botta A, Forest A, Daneault C, Pantopoulos K, Tantiworawit A, Phrommintikul A, Chattipakorn S, Chattipakorn N, Des Rosiers C & Sweeney G
Correlation of Plasma Lipidomic Profiles with Cardiometabolic Disease in Transfusion-dependent Thalassemia Patients with Six-month N-acetylcysteine Intervention: A Prospective Cohort Study.
Clinical Biochemistry (2025) 140:111030. doi: 10.1016/j.clinbiochem.2025.111030
Tang Y, Aleithan F, Madahar SS, Mirzaesmaeili A, Saran S, Tang J, Zangiabadi S, Inman R, Sweeney G, & Abdul-Sater AA
Selective disruption of Traf1/cIAP2 interaction attenuates inflammatory responses and rheumatoid arthritis. Journal of Autoimmunity (2025) 152:103377. doi: 10.1016/j.jaut.2025.103377.
Gandhi S, Delfinis LJ, Bhatt PD, Garibotti MC, Bellissimo C, Goli AN, Morris BA, Brahmbhatt AN, Yakobov-Shimonov S, Rahman3, Joe Quadrilatero FA, Simpson JA, Sweeney G, Abdul-Sater AA, Backx PH, Hsu HH, and Perry CGR
Adiponectin-receptor agonism prevents right ventricular tissue pathology in a mouse model of Duchenne muscular dystrophy
Molecular Metabolism (2025) 102179. doi: 10.1016/j.molmet.2025.102179
Nguyen C, Figueiroa RI, da Silva CM, Hatanaka E, Sweeney G, Lambertucci RH
Melatonin attenuates cardiac oxidative stress in diabetic rats following acute exhaustive exercise.
Cell Stress Chaperones. (2025) 30(6):100126. doi: 10.1016/j.cstres.2025.100126.
Cho S, Dadson K, Sung HK, Ayansola O, Mirzaesmaeili A, Noskovicova N, Zhao Y, Cheung K, Radisic M, Hinz B, Sater AAA, Hsu HH, Lopaschuk GD & Sweeney G
Cardioprotection by the adiponectin receptor agonist ALY688 in a preclinical mouse model of heart failure with reduced ejection fraction (HFrEF).
Biomedicine and Pharmacotherapeutics (2024) 171:116119
Nguyen K, Cho S, Tang J, Sung HK, Ying F, Pantopoulos K & Sweeney G
Salubrinal promotes phospho-eif2a-dependent activation of UPR leading to autophagy-mediated alleviation of iron overload-induced insulin resistance.
Molecular Metabolism (2024) 83:101921
Sung HK, Tang J, Jahng JSW, Song E, Chan C, Peterson J, Abdul-Sater AA, & Sweeney G
Ischemia-induced cardiac dysfunction is exacerbated in adiponectin-knockout mice due to impaired autophagy flux.
Clinical and Translational Science (2024) 17(3):e13758. doi: 10.1111/cts.13758.
Tang J, Lei Y, Pignalosa A, Hsu HH, Abdul-Sater AA & Sweeney G
Screening for blood-borne biomarkers of adiponectin action using the receptor agonist ALY688.
iScience (2024) 27(10):110994
Tam E, Song E, Noskovicova N, Hinz B, Xu A & Sweeney G
Autophagy deficiency exacerbated hypoxia-reoxygenation induced inflammation and cell death via a mitochondrial DNA/STING/IRF3 pathway
Life Sciences (2024) 358:123173
Lone AH, Tang J, Pignalosa A, Hsu HH, Abdul-Sater AA & Sweeney G
A novel blood-based bioassay to monitor adiponectin signaling.
International Immunopharmacology (2024) 132: 111890
Tang J, Tam E, Song E, Xu A, & Sweeney G
Crosstalk between myocardial autophagy and sterile inflammation in the development of heart failure.
Autophagy Reports (2024) 3(1) 2320605
Tam E, Nguyen K, Sung HK, & Sweeney G.
MitoNEET preserves muscle insulin sensitivity during iron overload by regulating mitochondrial iron, reactive oxygen species and fission
FEBS Journal (2024) doi: 10.1111/febs.17214
Tang J, Yoon N, Dadson K, Sung HK, Dang TQ, Lei Y, Chung WY, Wu J, Li RK Jonkman J, Peterson JD & Sweeney G
Impaired autophagy flux contributes to enhanced ischemia reperfusion injury in the diabetic heart
Autophagy Reports (2024) 3(1): 2330327
Huang Z, Sung HK, Yan X, He S, Jin L, Wang Q, Wu X, Sweeney G, & Xu A
A sustained release form of adiponectin-derived peptide ALY688 protects against the development of non-alcoholic steatohepatitis.
Clinical & Translational Science (2024) 17(6):e13760.
Gandhi S, Sweeney G & Perry CGR
Recent advances in developing adiponectin therapies for Duchenne muscular dystrophy
Biomedicines (2024) 12(7):1407
Bellissimo CA, Gandhi S, Castellani LN, Murugathasan M, Delfinis LJ, Thuhan A, Garibotti MC, Seo Y, Rebalka IA, Hsu HH, Sweeney G, Hawke TJ, Abdul-Sater AA, Perry CGR.
The slow-release adiponectin analogue ALY688-SR modifies early-stage disease development in the D2.mdx mouse model of Duchenne muscular dystrophy
American Journal of Physiology (Cell) (2024) 326(4):C1011-C1026
2023
Sung HK, Lam NH, Murugathasan M, Anwar S, Botelho R, Sater AA & Sweeney G.
Autophagy deficiency exacerbates iron overload induced reactive oxygen species production and apoptotic cell death in skeletal muscle cells
Cell Death & Disease (2023) 14(4):252
Tam E, Sung HK & Sweeney G.
MitoNEET prevents iron overload-induced insulin resistance in H9c2 cells through regulation of mitochondrial iron.
Journal of Cellular Physiology (2023) doi: 10.1002/jcp.31044
Liu Y, Fillebeen C, Forest A, Botta A, Varin TV, Marette A, Burelle Y, Des Rosiers C, Pantopoulos K, & Sweeney G.
Perturbations in lipid metabolism and gut microbiota composition precede cardiac dysfunction in a mouse model of thalassemia.
FASEB Journal (2023) (12):e23257. doi: 10.1096/fj.202301043R.
Tam E & Sweeney G.
MitoNEET provides cardioprotection via reducing oxidative damage and conserving mitochondrial function
International Journal of Molecular Sciences (2023) 25(1):480
Cho S, Ying F, & Sweeney G.
Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease
Biomedical Journal (2023) Jun 17:100624. doi: 10.1016/j.bj.2023.100624.
Reboucas P, Fillebeen C, Botta A, Cleverdon R, Steele AP, Richard V, Zahedi RP, Borchers CH, Burelle Y, Hawke TJ, Pantopoulos K, & Sweeney G.
Discovery-Based Proteomics Identify Skeletal Muscle Mitochondrial Alterations as an Early Metabolic Defect in a Mouse Model of β-Thalassemia
International Journal of Molecular Sciences (2023) 24(5):4402
Zangiabadi S, Chamoun KP, Tang Y, Nguyen K, Sweeney G, and Abdul-Sater AA.
Copper Fabric Attenuates Inflammation in Macrophages
Plos One (2023) 18(9):e0287741. doi: 10.1371/journal.pone.0287741
Bellissimo CA, Castellani LN, Finch MS, Murugathasan M, Gandhi S, Sweeney G, Abdul-Sater A. MacPherson REK & Perry CGR
Memory impairment in the D2.mdx mouse model of Duchenne muscular dystrophy is prevented by the adiponectin receptor agonist ALY688
Experimental Physiology (2023) 108(9):1108-1117. doi: 10.1113/EP091274
2022
Sung HK, Mitchell P, Gross S, Marette A & Sweeney G
ALY688 elicits adiponectin-mimetic signaling and improves insulin action in skeletal muscle cells
American Journal of Physiology (Cell) (2022) 322(2):C151-C163
Tam E, Sung HK, Lam NH, You S, Cho S, Ahmed S, Abdul-Sater A & Sweeney G
Role of mitochondrial iron overload in mediating cell death in H9c2 cells
Cells (2022) 28;12(1):118
Song E, Vu V, Varin TV, Botta A, Marette A & Sweeney G
Copper fabric improves metabolic profile of obese mice: potential role of the gut microbiota
Basic & Clinical Pharmacology & Toxicology (2022) 131(5):355-363
Importance of Autophagy in Mediating Cellular Responses to Iron Overload in Cardiomyocytes
Tam E, Reno C, Nguyen K, Cho S & Sweeney G.
Reviews in Cardiovascular Medicine (2022) 23(5), 167-181
Jin L, Geng L, Ying L, Shu L, Ye K, Yang R, Liu Y, Wang Y, Cai Y, Jiang X, Wang Q, Yan X, Liao B, Liu J, Duan F, Sweeney G, Woo C, Wang Y, Xia Z, Lian Q, & Xu A
The FGF21- Sirtuin 3 axis confers the protective effects of exercise against diabetic cardiomyopathy by governing mitochondrial integrity.
Circulation (2022) doi: 10.1161