Publications

2025

Perry CGR & Sweeney G

Targeting Scpep1 inhibition as a treatment in myocardial infarction: Editorial.

European Heart Journal (2025) 46(26):2595-2597.

Cho S, Tam E, Nguyen K, Lei Y, Fillebeen C, Pantopolous K, Sung HK, & Sweeney G

ω-6 PUFA-enriched cardiomyocyte membrane phospholipid composition increases the susceptibility to iron-induced ferroptosis and inflammation

Apoptosis (2025) doi: 10.1007/s10495-025-02121-0

Nguyen K, Tang J, Cho S , Gatica D, Russell RC, Sung HK & Sweeney G

ALY688 attenuates iron-induced ER stress and insulin resistance via activation of ER-phagy.

Diabetes (2025) 74(10):1761-1774.

Lei Y, Sung HK, Burger D & Sweeney G 

Strategies for Promoting Improved Healthspan: The Therapeutic Potential of Adiponectin and Extracellular Vesicles in Age-related Diseases

Ageing Research Reviews (2025) 111:102823. doi: 10.1016/j.arr.2025.102823

Chung WY, Kim Y, Cho S, Burger D & Sweeney G 

Role of Extracellular Vesicles in Pathogenesis of Cardiometabolic disease in Aging

Mechanisms of Ageing and Development (2025) 226:112078. doi: 10.1016/j.mad.2025.112078.

Sweeney G. & Burger D

Is secondary vesicle release an underappreciated component of extracellular vesicle signalling?

Journal of Extracellular Vesicles (2025: in press)

Tam E, Ouimet M, & Sweeney G

Role of adiponectin-stimulated autophagy in cardioprotection

Journal of Lipid & Atherosclerosis (2025) 14(1):40-53. doi: 10.12997/jla.2025.14.1.40.

Lei Y, Liu Y, Botta A, Forest A, Daneault C, Pantopoulos K, Tantiworawit A, Phrommintikul A, Chattipakorn S, Chattipakorn N, Des Rosiers C & Sweeney G

Correlation of Plasma Lipidomic Profiles with Cardiometabolic Disease in Transfusion-dependent Thalassemia Patients with Six-month N-acetylcysteine Intervention: A Prospective Cohort Study.

Clinical Biochemistry (2025) 140:111030. doi: 10.1016/j.clinbiochem.2025.111030

Tang Y, Aleithan F, Madahar SS, Mirzaesmaeili A, Saran S, Tang J, Zangiabadi S, Inman R, Sweeney G, & Abdul-Sater AA. Selective disruption of Traf1/cIAP2 interaction attenuates inflammatory responses and rheumatoid arthritis. Journal of Autoimmunity (2025) 152:103377. doi: 10.1016/j.jaut.2025.103377.

Gandhi S, Delfinis LJ, Bhatt PD, Garibotti MC, Bellissimo C, Goli AN, Morris BA, Brahmbhatt AN, Yakobov-Shimonov S, Rahman3, Joe Quadrilatero FA, Simpson JA, Sweeney G, Abdul-Sater AA, Backx PH, Hsu HH, and Perry CGR.

Adiponectin-receptor agonism prevents right ventricular tissue pathology in a mouse model of Duchenne muscular dystrophy

Molecular Metabolism (2025) 102179. doi: 10.1016/j.molmet.2025.102179

2024

Cho S, Dadson K, Sung HK, Ayansola O, Mirzaesmaeili A, Noskovicova N, Zhao Y, Cheung K, Radisic M, Hinz B, Sater AAA, Hsu HH, Lopaschuk GD & Sweeney G. Cardioprotection by the adiponectin receptor agonist ALY688 in a preclinical mouse model of heart failure with reduced ejection fraction (HFrEF). Biomedicine and Pharmacotherapeutics (2024) 171:116119 

Sung HK, Tang J, Jahng JSW, Song E, Chan C, Peterson J, Abdul-Sater AA, & Sweeney G. Ischemia-induced cardiac dysfunction is exacerbated in adiponectin-knockout mice due to impaired autophagy flux. Clinical and Translational Science (2024) 17(3):e13758. doi: 10.1111/cts.13758.

Tang J, Tam E, Song E, Xu A, & Sweeney G. Crosstalk between myocardial autophagy and sterile inflammation in the development of heart failure. Autophagy Reports (2024) 3(1) 2320605

Nguyen K, Cho S, Tang J, Sung HK, Ying F, Pantopoulos K & Sweeney G. Salubrinal promotes phospho-eif2a-dependent activation of UPR leading to autophagy-mediated alleviation of iron overload-induced insulin resistance. Molecular Metabolism (2024) 83:101921

Lone AH, Tang J, Pignalosa A, Hsu HH, Abdul-Sater AA & Sweeney G. A novel blood-based bioassay to monitor adiponectin signaling. International Immunopharmacology (2024) 132: 111890

Tam E, Nguyen K, Sung HK, & Sweeney G. MitoNEET preserves muscle insulin sensitivity during iron overload by regulating mitochondrial iron, reactive oxygen species and fission. FEBS Journal (2024) doi: 10.1111/febs.17214

Tang J, Yoon N, Dadson K, Sung HK, Dang TQ, Lei Y, Chung WY, Wu J, Li RK, Jonkman J, Peterson JD & Sweeney G. Impaired autophagy flux contributes to enhanced ischemia reperfusion injury in the diabetic heart. Autophagy Reports (2024) 3(1): 2330327

Huang Z, Sung HK, Yan X, He S, Jin L, Wang Q, Wu X, Sweeney G, & Xu A. A sustained release form of adiponectin-derived peptide ALY688 protects against the development of non-alcoholic steatohepatitis. Clinical & Translational Science (2024) 17(6):e13760. 

Tang J, Lei Y, Pignalosa A, Hsu HH, Abdul-Sater AA & Sweeney G. Screening for blood-borne biomarkers of adiponectin action using the receptor agonist ALY688. iScience (2024) 27(10):110994

Gandhi S, Sweeney G & Perry CGR. Recent advances in developing adiponectin therapies for Duchenne muscular dystrophy. Biomedicines (2024) 12(7):1407

Bellissimo CA, Gandhi S, Castellani LN, Murugathasan M, Delfinis LJ, Thuhan A, Garibotti MC, Seo Y, Rebalka IA, Hsu HH, Sweeney G, Hawke TJ, Abdul-Sater AA & Perry CGR.

The slow-release adiponectin analogue ALY688-SR modifies early-stage disease

development in the D2.mdx mouse model of Duchenne muscular dystrophy

American Journal of Physiology (Cell) (2024) 326(4):C1011-C1026

Tam E, Song E, Noskovicova N, Hinz B, Xu A & Sweeney G

Autophagy deficiency exacerbated hypoxia-reoxygenation induced inflammation and cell

death via a mitochondrial DNA/STING/IRF3 pathway 

Life Sciences (2024) 358:123173